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"CTRI Bulletin"
#4,(9),2019.

CTRI BULLETIN №4 (9) 2019

Journal Information: Read
Chief Editor: Ergeshov A.E.
Year of foundation: 2017
ISSN (Print): Browse
Publisher site: http://critub.ru
http://tb-bulletin.ru

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CONTENT

1)

Acute phase reactants and nutritional status markers in patients with TB/HIV co-infection

Abdullaev R.Yu., Komissarova O.G., Gerasimov L.N.

5 READ MORE
2)

Disseminated lung lesions in patients with late-stage HIV disease with immunosuppression

Mishin V.Yu., Mishina A.V., Ergeshov A.E., Romanov V.V.

14 READ MORE
3)

Acute phase reactants in treatment of pulmonary TB patients with diabetes mellitus

Berezhnaya O.O., Abdullaev R.Yu., Komissarova O.G., Romanov V.V.

30 READ MORE
4)

Tuberculous peritonitis in HIV infection

Sinitsyn M.V., Plotkin D.V., Abu Arkub T.I., Reshetnikov M.N., Barsky B.G.

38 READ MORE
5)

Epidemiological, immunological and clinical manifestations of TB in preschool children and junior schoolchildren

Aroyan A.R.

45 READ MORE
6)

The role of specific clinical and anamnestic data in the development of extrapulmonary TB in children  

Porkulevich N.I.

52 READ MORE
7)

Peculiarities of primary diagnosis of sarcoidosis in association with ischemic heart disease

Abubikirov A.F., Leonova E.I., Mazaeva L.A., Medvedev A.V., Shmelev E.I.

59 READ MORE
8)

Modern opportunities and priorities of tuberculosis control in the Republic of Moldova (dedicated to the 60th anniversary of Kirill Draganyuk Phthisiopulmonology Institute)

Javorsky K.M., Aleksandru S.M., Vilk V.V., Tudor E.M., Donika A.F., Bolotnikova V.A., Moskovchuc A.F., Brumaru A.G., Korlotyanu A.A.

70 READ MORE
9)

In vitro activity of nanosilver comvbination with isoniazid and rifampicin against Mycobacterium tuberculosis

Nikonenko B.V., Majorov K.B., Revina A.A., Zakharov A.V., Ergeshov A.E.

76 READ MORE 
10)

Detection of mycobacteriaby luminescence microscopy. Part 2. Microscopic study of smears

Sevastyanova E.V., Larionova E.E., Andrievskaya I.Yu., Smirnova T.G.

81 READ MORE 

ACUTE PHASE REACTANTS AND NUTRITIONAL STATUS MARKERS IN PATIENTS WITH TB/HIV CO-INFECTION

Article 1.Page 5.
ARTICLE TITLE:

Acute phase reactants and nutritional status markers in patients with tb/hiv co-infection

DOI: 10.7868/S2587667819040010

AUTORS:

Abdullaev R.Yu.1, Komissarova O.G.1,2, Gerasimov L.N.1,3

1 Central TB Research Institute, Moscow, Russia

2 Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia

3 Tuberculosis Hospital named after A.E. Rabukhin, Moscow, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 06.03.2019

In the recent years the problem of TB/HIV co-infection has been attracting more and more attention. Intense interest was aroused due to continuous growth of TB incidence among HIV patients. HIV infection is a risk factor for developing TB. The course and the outcome of TB in HIV patients depend on the non-specific reactivity of the host’s organism, i.e. the ability to react to a causative agent with a complex of protective reactions. The systemic inflammatory response (SIR) is one of such reactions. The key components of SIR are increasing synthesis and release of proteins with specific protective functions, so-called acute phase reactants (APR). The process is accompanied by decreasing synthesis of transporters in the liver. The problem of TB/HIV co-infection should be urgently addressed, since it is important to understand the mechanisms of TB process in such patients. We have reviewed the data related to laboratory presentations of SIR in TB/HIV patients, including APR levels (CRP, α1-antitrypsin, haptoglobin, fibrinogen) and nutritional status markers (BMI, transthyretin, albumin).

The article was prepared in the framework of scientific research no. 0515-2015-0015 “Modern approaches to diagnosis, epidemiology and treatment of drug resistant pulmonary TB, including TB associated with HIV infection or diabetes mellitus”.

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KEYWORDS:

TB, HIV infection, systemic inflammatory response, acute phase reactants, nutritional deficiency, transthyretin.

FOR CORRESPONDENCE:

Central ТВ Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Rizvan Yu. Abdullaev, Doctor of Medical Sciences, Professor, Head of Biochemistry Laboratory

Tel.: +7 (499) 748-30-23

E-mail: rizvan0403@yandex.ru

Oksana G. Komissarova, Doctor of Medical Sciences, Deputy Director for Research and Treatment, Professor of Phthisiology Department of Russian National Research Medical University named after N.I. Pirogov

Tel.: +7 (499) 785-90-60

E-mail: okriz@rambler.ru

Tuberculosis Hospital named after A.E. Rabukhin

7, Rabukhin St., 141504, Solneshnogorsk, Moscow region

Lev N. Gerasimov, phthisiologist 

Tel.: +7 (495) 780-69-08

E-mail: 1968berserc@mail.ru

DISSEMINATED LUNG LESIONS IN PATIENTS WITH LATE-STAGE HIV DISEASE WITH IMMUNOSUPPRESSION

Article 2.Page 14.
ARTICLE TITLE:

Disseminated lung lesions in patients with late-stage Hiv disease with immunosuppression

DOI: 10.7868/S2587667819040022

AUTORS:

Mishin V.Yu.1, 2, Mishina A.V.1, Ergeshov A.E.2, Romanov V.V.2

1 A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

2 Central TB Research Institute, Moscow, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 21.02.2019

We have presented the literature data on disseminated lung lesions in patients with late-stage HIV disease with immunosuppression. We reviewed the most urgent issues of diagnosis and clinical manifestations of disseminate lung lesions accompanied by different secondary comorbidities typical for late-stage HIV patients with immunosuppression. Phthisiologists, pulmonologists, infectiologists, therapeutists and other medical specialists should have understanding of such a pathology to timely diagnose disseminated lung lesions in patients with late-stage HIV disease. They should conduct comprehensive clinical, radiological, laboratory studies to choose adequate tactics of patient management. The most frequent disseminated lung lesions in patients with late-stage HIV disease with immunosuppression are tuberculosis, non-tuberculous mycobacterioses, pneumocystis pneumonia, and atypical pneumonias caused by viruses, bacteria, fungi or parasites.

The article was prepared in the framework of scientific research no. 0515-2015-0015 “Modern approaches to diagnosis, epidemiology and treatment of drug resistant pulmonary TB, including TB associated with HIV infection or diabetes mellitus”.

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KEYWORDS:

HIV disease, immunosuppression, disseminated lung lesions, tuberculosis, differential diagnosis.

FOR CORRESPONDENCE:

A.I. Evdokimov Moscow State University of Medicine and Dentistry

20/1, Delegatskaya ul., 127473, Moscow, Russia

Central TB Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Vladimir Yu. Mishin, Doctor of Medical Sciences, Professor, Head, Phthisiology and Pulmonology Department, A.I. Evdokimov Moscow State University of Medicine and Dentistry; Principal Researcher, Central TB Research Institute

Tel.: +7 (910) 436-56-88

Е-mail: mishin.vy@mail.ru

A.I. Evdokimov Moscow State University of Medicine and Dentistry

20/1, Delegatskaya ul., 127473, Moscow, Russia

Anastasia V. Mishina, Candidate of Medical Sciences, Assistant, Phthisiology and Pulmonology Department

Tel.: +7 (910) 459-18-90

Е-mail: av.mishina@yandex.ru

Central TB Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Atadzhan E. Ergeshov, Doctor of Medical Sciences, Professor, Director

Tel.: +7 (499) 785-90-19

E-mail: cniit@ctri.ru

Vladimir V. Romanov, Doctor of Medical Sciences, Professor, Head of Phthisiology Department

Tel.: +7 (916) 169-84-60

E-mail: romanov-vladimir.nkj@yandex.ru

ACUTE PHASE REACTANTS IN TREATMENT OF PULMONARY TB PATIENTS WITH DIABETES MELLITUS

Article 3.Page 30.
ARTICLE TITLE:

Acute phase reactants in treatment of pulmonary tb patients with diabetes mellitus

DOI: 10.7868/S2587667819040034

AUTORS:

Berezhnaya O.O.1,2, Abdullaev R.Yu.1, Komissarova O.G.1,2, Romanov V.V.1

1 Central TB Research Institute, Moscow, Russia

2 N.I. Pirogov Russian National Research Medical University, Moscow, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 10.04.2019

Aim. To study the dynamics of acute phase reactants (APR) in the complex treatment of pulmonary TB patients with different types diabetes mellitus (DM) before and during treatment.

Materials and methods. We studied 100 pulmonary TB patients divided in two groups. Group 1 included 40 pulmonary TB patients with type 1 DM. Group 2 included 60 pulmonary TB patients with type 2 DM. We determined the levels of C-reactive protein (CRP), serum amyloid A (SAA) protein, α1-antitrypsin (α1-АТ), haptoglobin (Hp) and fibrinogen (F). These studies were performed before treatment and on a monthly basis during the first 6 months of treatment.

Results and conclusions. We established that in patients with the both diseases the dynamics of APR directly depended on treatment effectiveness. By the end of a six-month course the levels of APR came to the norm in patients with the either type DM, though α1-АТ remained moderately elevated. This witnessed incompleteness of inflammatory process and possible activation of limited proteolysis reactions during reparative processes. However, some indicators changed in patients with different types DM at different rates. Normalization of most APR during effective treatment of patients with type 2 DM was slower. Different rates of reduction or normalization of individual APR in patients with different types DM, apparently, were associated with the peculiarities of the host’s protective reactions, which slowed down as infection aggression was over and inflammation was resolved. Treatment failure led to delayed and incomplete positive dynamics of CRP and SAA; initially high values of α1-АТ and Hp did not change during the whole course of treatment.

The research was conducted under scientific research theme no. 0515-2015-0015 “Modern approaches to diagnosis, epidemiology and treatment of drug resistant pulmonary TB, including HIV- and diabetes mellitus-associated TB”.

REFERENCES:
  1. Dedov I.I., Shestakova M.V. , Vikulova O.K., Zheleznyakova A.V., Isakov M.A. Diabetes mellitus in the Russian Federation: prevalence, incidence, mortality, parameters of carbohydrate metabolism, and the structure of antihyperglycemic treatment according to the Federal register of diabetes mellitus, 2017. Sakharny diabet, 2018, vol. 21, no. 3, pp. 144–159. (In Russ.)
  2. Kaminskaya G.O., Abdullaev R.Yu., Komissarova O.G. The state of protein metabolism as factor of nonspecific reactivity of pulmonary TB patients. Tuberculosis and Lung Diseases, 2012., no. 12, pp. 30–35. (In Russ.)
  3. Kaminskaya G.O., Abdullaev R.Yu. Pathophysiological preconditions of unfavourable impact of diabetes mellitus on the course of pulmonary TB. Tuberculosis and Lung Diseases, 2014, no. 3, pp. 5–10. (In Russ.)
  4. Kaminskaya G.O., Abdullaev R.Yu., Komissarova O.G. The peculiarities of the systemic inflammatory response syndrome and the nutritive status of pulmonary TB patients with concomitant type 1 or type 2 diabetes mellitus. Tuberculosis and Lung Diseases, 2017, vol. 95,
  5. no. 3, pp. 32–40. (In Russ.) DOI:10.21292/2075-1230-2017-95-3-32-4
  6. Komissarova O.G., Abdullaev R.Yu., Mikhailovsky A.M. Diabetes mellitus as risk factor for TB: pathophysiological aspects. Medicinsky alyans, 2017, no. 3, pp. 28–34. (In Russ.)
  7. Komissarova O.G., Abdullaev R.Yu., Konyaeva O.O., Mikhailovsky A.M. Prevalence, clinical presentations and effectiveness of TB treatment in diabetes mellitus patients. Vrach, 2017, no. 2, pp. 24–28. (In Russ.)
  8. Komissarova O.G., Abdullaev R.Yu., Lepekha L.N., Erokhin V.V. Drug resistant pulmonary TB at different intensities of the systemic inflammatory response syndrome. Moscow, U Nikitskikh vorot, 2013, 168 p. (In Russ.)
  9. Smurova T.F., Kovaleva S.I. TB and diabetes mellitus. Moscow, Medkniga, 2007, 317 p. (In Russ.)
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  11. DF diabetes atlas – 2017. 8th Edition. IDF [Official website]. http://www.idf.org/diabetesatlas
  12. Jeon C.Y., Murray M.B. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med., 2008, vol. 5, no. 7, pp. e152.
  13. Ronacher K., van Crevel R., Critchley J.A. et al. Defining a research agenda to address the converging epidemics of tuberculosis and diabetes: Part 2: Underlying biologic mechanisms. Chest, 2017, vol. 152, no. 1, pp. 174–180.
  14. Unsal E., Aksaray S., Koksal D., Sipit T. Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Med., 2005, vol. 81, pp. 604–607.
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KEYWORDS:

TB, diabetes mellitus, acute phase reactants, C-reactive protein, serum amyloid A protein, α1-antitrypsin, haptoglobin, fibrinogen.

FOR CORRESPONDENCE:

Central ТВ Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Olga O. Berezhnaya, MD, phthisiologist of Therapeutic Department no. 3, Central TB Research Institute; Assistant, Phthisiology Department, N.I. Pirogov Russian National Research Medical University

Tel.: +7 (499) 785-90-71

E-mail: olga.berejnaya12@gmail.com

Rizvan Yu. Abdullaev, Doctor of Medical Sciences, Professor, Leading Researcher, Department of Pathological Anatomy, Cell Biology and Biochemistry, Head of Biochemistry Laboratory

Tel.: +7 (499) 785-90-71

E-mail: rizvan0403@yandex.ru

Oksana G. Komissarova, Doctor of Medical Sciences, Deputy Director for Research and Treatment, Central TB Research Institute; Professor of Phthisiology Department, N.I. Pirogov Russian National Research Medical University

Tel.: +7 (903) 118-48-18

E-mail: oksana.komissarova.72@mail.ru

Vladimir V. Romanov, Doctor of Medical Sciences, Professor, Head, Phthisiology Department

Tel.: +7 (499) 785-90-71

E-mail: romanov-vladimir-vik@yandex.ru

TUBERCULOUS PERITONITIS IN HIV INFECTION

Article 4.Page 38.
ARTICLE TITLE:

Tuberculous peritonitis in hiv infection

DOI: 10.7868/S2587667819040046

AUTORS:

Sinitsyn M.V.1, Plotkin D.V.1,2, Abu Arkub T.I.1, Reshetnikov M.N.1, Barsky B.G.1

1 Moscow Research and Clinical Center for Tuberculosis Control of Moscow Government Health Department, Moscow, Russia

2 N.I. Pirogov Russian National Research Medical University, Moscow, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 05.07.2019

Abdominal TB in HIV-positive patients is usually asymptomatic and chronic; manifestations occur at development of various complications described as “acute abdomen”.

Aim: To compare informativity of diagnostic video-laparoscopy and radiologic methods in diagnosing tuberculous peritonitis in HIV patients.

Materials and methods. In 2014–2018, 52 tuberculous peritonitis patients (including 14 HIV patients) underwent medical examinations and surgery at the TB surgery department of the Moscow Research and Clinical Center for Tuberculosis Control.

Results and discussion. The radiological methods were informative in only half of the patients. Diagnostic laparoscopy followed by exudate studies and peritoneal biopsy showed more accurate diagnostic results. In the most cases, due to similarities of the laparoscopic features, it was necessary to carry out differential diagnosis with peritoneal carcinomatosis and abdominal adhesive disease.

Conclusion. In HIV patients, tuberculous peritonitis course is latent with various manifestations. The radiological studies cannot reveal the nature of abdominal changes. Low specificity of adenosine deaminase (ADA) activity in HIV patients, low detection of M. tuberculosis DNA and M. tuberculosis by PCR testing of exudate swabs makes laparoscopy with biopsy the only reliable method of abdominal TB diagnosis, including in HIV patients.

REFERENCES:
  1. Нечаева О.Б. Эпидемическая ситуация по туберкулезу среди лиц с ВИЧ-инфекцией в Российской Федерации // Туберкулез и болезни легких. – 2017. – Т. 95. – № 3. – С. 13–19.
  2. Савоненкова Л.Н., Анисимова С.В., Сидорова Ю.Д., Сидоров И.А., Чунина А.Ф. Летальность больных туберкулезом в условиях эпидемии ВИЧ-инфекции // Ульяновский медико-биологический журнал. – 2018. – № 3. – С. 99–106.
  3. Синицын М.В., Белиловский Е.М., Соколина И.А., Решетников М.Н., Титюхина М.В., Батурин О.В. Внелегочные локализации туберкулеза у больных ВИЧ-инфекцией // Туберкулез и болезни легких. – 2017. – Т. 95. – № 11. – С. 19–25. https://doi.org/10.21292/2075-1230-2017-95-11-19-25
  4. Cavalli Z., Ader F., Valour F., Saison J., Boussel L.,Dumitrescu O. Clinical presentation, diagnosis, and bacterial epidemiology of peritoneal tuberculosis in two university hospitals in France. Infectious Diseases and Therapy, 2016, no. 5, pp. 193–199. DOI: 10.1007/s40121-016-0113-2
  5. Chow K.M., Chow V.C., Szeto C.C. Indication for peritoneal biopsy in tuberculous peritonitis. The American Journal of Surgery, 2003, vol. 185, no. 6, pp. 567–573.
  6. Getahun H., Gunneberg C., Granich R., Nunn P. HIV infection associated tuberculosis: the epidemiology and the response, Clinical Infectious Diseases, 2010, vol. 50, no. 3, pp. 201–207. DOI: 10.1086/651492
  7. Kaushik R., Punia R., Mohan H., Attri A.K. Tuberculous abdominal cocoon – a report of 6 cases and review of the literature. World Journal of Emergency Surgery, 2006, no. 1, pp. 18–26. DOI: 10.1186/1749-7922-1-18
  8. Kaya M., Kaplan M.A., Isikdogan A., Celik Y. Differentiation of tuberculous peritonitis from peritonitis carcinomatosa without surgical intervention. Saudi Journal of Gastroenterology, 2011, vol. 17, no. 5, pp. 312–317. DOI: 10.4103/1319-3767.84484
  9. Ko dmo n C., Zucs P., Van der Werf M.J. Migrationrelated tuberculosis: Epidemiology and characteristics of tuberculosis cases originating outside the European Union and European Economic Area, 2007 to 2013. EuroSurveill, 2016, no. 12, pp. 21. DOI: 10.2807/1560-7917.ES.2016.21.12.30164
  10. Salgado Floresa L., Herna’ndez Sol sa А., Escobar А. Peritoneal tuberculosis: A persistent diagnostic dilemma, use complete diagnostic methods. Revista Me’dica del Hospital General de Me’xico, 2015, vol. 78, no. 2, pp. 55–61. https://doi.org/10.1016/j. hgmx.2015.03.009
  11. Sanai F.M., Bzeizi K.I. Systematic review: Tuberculous peritonitis – Presenting features, diagnostic strategies and treatment. Alimentary Pharmacology & Therapeutics, 2005, no. 22, pp. 685–700. DOI: 10.1111/j.1365-2036.2005.02645.x
  12. Shen Y.C., Wang T., Chen L. Diagnostic accuracy of adenosine deaminase for tuberculous peritonitis: a meta-analysis. Archives of Medical Science, 2013, no. 9, pp. 601–609. DOI: 10.5114/aoms.2013.36904
  13. Srivastava U., Almusa О., Ka-wah Tung, Heller М.Т. Tuberculous peritonitis. Radiology Case Reports, 2014, vol. 9, no. 3, р. 971, https://doi.org/10.2484/rcr.v9i3.971
  14. Vaid U., Kane G.C. Tuberculous peritonitis. Microbiology Spectrum, 2017, vol. 5, no. 1, pp. 1–2. DOI: 10.1128/microbiolspec.TNMI7-0006-2016
KEYWORDS:

abdominal tuberculosis, HIV infection, diagnosis, video laparoscopy.

FOR CORRESPONDENCE:

Moscow Research and Clinical Center for Tuberculosis Control of Moscow Government Health Department

10, Stromynka St., 107014, Moscow, Russia

Mikhail V. Sinitsyn, Candidate of Medical Sciences, Acting Director

Tel.: +7 (910) 462-42-54

E-mail: msinitsyn@mail.ru

Dmitry V. Plotkin, Candidate of Medical Sciences, Surgeon, Tuberculosis Surgery Department no. 2; Docent, General Surgery and Radiology Diagnosis Department, Treatment Faculty, N.I. Pirogov Russian National Research Medical University

Tel.: +7 (916) 125-89-21

E-mail: kn13@list.ru

Tamila I. Abu Arkub, Surgeon, Tuberculosis Surgery Department no. 2

Tel.: +7 (499) 268-25-00

E-mail: tamila89.07@mail.ru

Mikhail N. Reshetnikov, Candidate of Medical Sciences, Surgeon, Tuberculosis Surgery Department no. 2

Tel.: +7 (499) 268-25-00

E-mail: taxol@bk.ru

Boris G. Barsky, Candidate of Medical Sciences, Head, Tuberculosis Surgery Department no. 2

Tel.: +7 (499) 268-25-00

E-mail: bbarsky@mail.ru

EPIDEMIOLOGICAL, IMMUNOLOGICAL AND CLINICAL MANIFESTATIONS OF TB IN PRESCHOOL CHILDREN AND JUNIOR SCHOOLCHILDREN

Article 5.Page 45.
ARTICLE TITLE:

Epidemiological, immunological and clinical manifestations of tb in preschool children and junior schoolchildren

DOI: 10.7868/S2587667819040058

AUTORS:

Aroyan A.R.

Omsk State Medical University, Omsk, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 30.06.2019

Preschool and junior school age are special for TB infection. Researchers and child TB physicians observe a large share of TB infection and TB disease in these age groups, which is due to expanding contacts of growing children. In the article you will find the results of a retrospective study of 609 children aged 4–1 in Omsk region. They all were ill with TB and received inpatient treatment in 2001–2018. Epidemiological, immunological and clinical manifestations of TB were described for further improvement of diagnostic and preventive procedures.

REFERENCES:
  1. Aksenova V.A., Baryshnikova L.A., Dolzhenko E.N., Kudlai D.A. The urgent issues of mass screening of children for TB in the present situation. ru, 2012, vol. 76, no. 8, pp. 27–29. (In Russ.)
  2. Aksenova V.A., Baryshnikova L.A., Klevno N.I., Sokolskaya E.A., Dolzhenko E.N., Shuster A.M., Martyanov V.A., Kudlai D.A., Nikolenko N.Yu., Kurilla A.A. New perspectives of screening and diagnosis of different manifestations of TB infection in children and adolescents in Russia. Voprosy Sovremennoi Pediatrii, 2011, vol. 10., no. 4, pp. 16–22. (In Russ.)
  3. Aksenova V.A., Klevno N.I., Baryshnikova L.A., Kudlai D.A., Nikolenko N.Yu., Kurilla A.A. Methodical recommendations: TB detection and tactics of dispensary follow-up of risk groups using recombinant tuberculosis allergen, Diaskintest. Moscow, 2011, 12 p. (In Russ.)
  4. Aksenova V.A., Levi D.T., Aleksandrova N.V., Kudlai D.A. The current state of childhood TB incidence, drugs for TB prevention and diagnosis. Profilaktika, diagnostika, lechenie, 2017, vol. 17, no. 3, pp. 145–151. (In Russ.)
  5. Vasilyeva I.A., Belilovsky E.M., Borisov S.E., Sterlikov S.A. The World Health Organization global tuberculosis reports: compilation and interpretation. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 5, pp. 7–16. (In Russ.)
  6. Mordyk A.V., Tsygankova E.A., Aroyan A.R. Methods of TB detection in early age children in different time periods. Poliklinika, 2015, no. 2–2, pp. 38–42. (In Russ.)
  7. Romanova M.A., Mordyk A.V. Modern methods of immunodiagnosis for detection of different forms of TB in different anatomical sites in children with concomitant pathology. Jurnal imeni G.N. Speranskogo, 2016, vol. 95, no. 2, pp. 77–82. (In Russ.)
  8. Romanova M.A., Mordyk A.V., Leontyeva E.S. Age features of concomitant pathology in children with TB. Mat i ditya v Kuzbasse, 2015, vol. 60, no. 1, pp. 39–43. (In Russ.)
  9. Romanova M.A., Mordyk A.V., Tsygankova E.A. The structure of clinical forms of TB and concomitant pathology in children related to social marginality of their families. Tuberculosis and Lung Diseases, 2015, no. 7, pp. 120–121. (In Russ.)
  10. Tsygankova E.A., Mordyk A.V. Age features of clinical manifestation of childhood TB. Omsky nauchny vestnik, 2012, vol. 108, no. 1, pp. 72–75. (In Russ.)
  11. Benin S. Ade et al. The burden and outcomes of childhood tuberculosis in Cotonou, International Union Against Tuberculosis and Lung Disease, 2013, vol. 3, no. 1, pp. 15–19.
  12. Delacourt C. Specific features of tuberculosis in childhood. Rev Mal Respir., 2011, vol. 28, pp. 529–541.
  13. Nahid P. et al. Official American Thoracic Society, Centers for Disease Control and Prevention, Infectious Diseases Society of America Clinical Practice Guidelines: treatment of drug-susceptible tuberculosis. Infect. Dis., 2016, vol. 63, pp. 147–195.
  14. Preez K. Du et al. Incomplete registration and reporting of culture-confirmed childhood tuberculosis diagnosed in hospital. PublicHealthAction, 2011, vol. 1, no. 1, pp. 19–24.
  15. Perez-Velez C.M., Marais B.J. Tuberculosis in children. Engl. J. Med., 2012, vol. 367, pp. 348–361.
  16. Seddon J.A., Shingadia D. Epidemiology and disease burden of tuberculosis in children: a global perspective. Infection and Drug Resistance, 2014, vol. 7, pp. 153–165.
  17. Swaminathan S., Rekha B. Pediatric tuberculosis: global overview and challenges. Infect. Dis., 2010, vol. 50, no. 3, pp. 184–194.
  18. World Health Organization. WHO Report; 2017 [Electronic resource]. URL: www.who.int
KEYWORDS:

TB, junior school age, preschool children, infection, diagnosis.

FOR CORRESPONDENCE:

Omsk State Medical University

12, Lenin St., 644099, Omsk, Russia

Anna R. Aroyan, Assistant, Phthisiology, Phthisiosurgery and Infectious Diseases Department

Тел.: +7 (381) 240-45-15

Е-mail: аnna.aroyan@yandex.ru

THE ROLE OF SPECIFIC CLINICAL AND ANAMNESTIC DATA IN THE DEVELOPMENT OF EXTRAPULMONARY TB IN CHILDREN

Article 6.Page 52.
ARTICLE TITLE:

The role of specific clinical and anamnestic data In the development of extrapulmonary tb in children

DOI: 10.7868/S258766781904006X

AUTORS:

Porkulevich N.I.

Omsk State Medical University, Omsk, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 30.06.2019

The main risk factors for the development of active TB in children are: pronounced or hyperergic reactions to tuberculin, living in antisocial or sociodemographic risk families, exposure to TB, comorbidities, primary infection, absent or ineffective BCG vaccination. Presently, there are very few researches, which reflect the role of specific risk factors for the development of extrapulmonary TB. In this article the most significant risk factors for the development of extrapulmonary TB in children in Omsk region are outlined based on the analysis of anamnestic and clinical data, family social status, epidemiological anamnesis.

REFERENCES:
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  2. Aksenova V.A., Baryshnikova L.A., Klevno N.I., Sokolskaya E.A., Dolzhenko E.N., Shuster A.M., Martyanov V.A., Kudlai D.A., Nikolenko N.Yu., Kurilla A.A. New opportunities of screening and diagnosis of different manifestations of TB infection in children and adolescents in Russia. Voprosy sovremennoi pediatrii, 2011, vol. 10, no. 4, pp. 16–22. (In Russ.)
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  4. Drobot N.N., Shevchenko N.P., Molchanova N.V. The peculiarities of TB epidemiology – socially dangerous diseases in children and adolescents in the present conditions. Vyatsky medicinsky vestnik, 2015, vol. 2, no. 2, pp. 42–44. (In Russ.)
  5. Latent TB infection (LTI) in children. Clinical recommendations. Moscow, 2016, 44 p. (In Russ.)
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  21. Wiseman C.A., Starke J.R., Gie R.P., Schaaf H.S. A proposed comprehensive classification of tuberculosis disease severity in children. The Pediatric Infectious Disease Journal, 2012, no. 31 (4), pp. 347–352.
KEYWORDS:

children, TB, extrapulmonary TB, risk factors, infection, clinical forms of TB.

FOR CORRESPONDENCE:

Omsk State Medical University

8a, Khimikov St., 644050, Omsk, Russia

Nadezhda I. Porkulevich, Postgraduate Student, Department of Phthisiology, Phthisiosurgery

and Infectious Diseases

Tel.: +7 (908) 107-30-73

Е-mail: nkul@mail.ru

PECULIARITIES OF PRIMARY DIAGNOSIS OF SARCOIDOSIS IN ASSOCIATION WITH ISCHEMIC HEART DISEASE

Article 7.Page 59.
ARTICLE TITLE:

Peculiarities of primary diagnosis of sarcoidosis in association with ischemic heart disease

 DOI: 10.7868/S2587667819040071

AUTORS:

Abubikirov A.F., Leonova E.I., Mazaeva L.A., Medvedev A.V., Shmelev E.I.

Central TB Research Institute, Moscow, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 14.03.2019

Diagnosis of pulmonary and intrathoracic lymph node (ITLN) sarcoidosis in association with ischemic heart disease (IHD) remains inadequate. More than one third of patients receive long courses of TB treatment or corticosteroids instead of rational and active complementary diagnostic procedures. The frequency of diagnostic errors is high – 50–70%. Aim: To establish causes of diagnostic errors and detect peculiarities of sarcoidosis diagnosis in IHD patients. Materials and methods: We carried out a study at the pulmonology department of the Central TB Research Institute. We analyzed diagnostic results obtained in 49 patients with pulmonary/ITLN sarcoidosis without IHD and 38 patients with pulmonary/ITLN sarcoidosis in association with IHD. Results and discussion. In IHD patients errors in sarcoidosis diagnosis occurred 1.35 times oftener than in non-IHD patients. The errors were due to misunderstanding of symptoms (13.5% of patients), misreading of functional (18.41%) or X-ray (28.93%) study results. The underlying cause was insufficient use of modern diagnostic methods, including chest CT, bronchological studies, morphological verification. Conclusion. Difficulties in pulmonary/ITLN sarcoidosis diagnosis were observed in 60.49% of IHD patients. The primary diagnostic errors were attributed to few symptoms at the initial stages of the disease, discordance between clinical manifestations and the lung changes, scanty functional disturbances. The worst difficulties were encountered at differentiating with pulmonary TB (12.24%), cancer (8.16%), community acquired pneumonia (5.26%). Timely use of modern diagnostic methods (chest CT, morphological verification of the diagnosis) would reduce the number of diagnostic errors 1.34 times.

The research was conducted under scientific theme no. 0515-2019-00-14 “Improving the treatment of granulomatous, interstitial and non-specific lung diseases.”

REFERENCES:
  1. Ageev A.T., Skvortsov N.A. Heart failure in IHD patients. Some issues of pathogenesis and treatment. Russky medicinsky jurnal, 2000, no. 15, pp. 622–626. (In Russ.)
  2. Bolotova E.V., Shulzhenko L.V., Porkhanov V.A. Mistakes in diagnosis of interstitial lung diseases before hospitalization. Pulmonologia, 2015, no. 25, pp. 41– 44. (In Russ.)
  3. Vizel I.Yu., Vizel A.A. The analysis of clinical diagnosis of sarcoidosis in new organizational settings. Prakticheskaya medicina, 2013, no. 5, pp. 68–71. (In Russ.)
  4. Vizel A.A., Sozinov A.S., Farrakhov A.Z., Tuishev R.I., Potanin V.P., Amirov N.B., Guslyakova R.P., Safin I.N., Vizel I.Yu., Potanin A.E. Provision of health care of sarcoidosis patients in the Republic of Tatarstan.Effektivnaya famakoterapiya: pulmonologia i otolaringologia, 2011, no. 4, pp. 6–11. (In Russ.)
  5. Diagnosis and treatment of chronic ischemic heart disease. Clinical recommendations. Moscow, 2013. (In Russ.)
  6. Dmitrieva L.I., Sigaev A.T., Romanov V.V. Radiology diagnosis of pulmonary sarcoidosis. Problems of Tuberculosis, 2001, no. 2, pp. 56–61. (In Russ.)
  7. Ilkovich M.M., Abumislimova E.A., Grigorieva N.O., Dzazua D.V. Quality assessment of diagnosis of interstitial lung diseases at ambulatory stage. Pulmonologia, Abstract compilation, the 16th National congress on pulmonary diseases. Abstract 330, p. 92. (In Russ.)
  8. National guidelines. Short edition. Ed. by A.G. Chuchalin, Moscow, Geotar-Media, 2013, pp. 548–564. (In Russ.)
  9. Monograph. Ed. by A.A. Vizel. Moscow, Atmosfera, 2010, pp. 220–239. (In Russ.)
  10. Stable ischemic heart disease. Clinical recommendations. Moscow, Medicine, 2016. (In Russ.)
  11. Bicanic V. et al. Functional diagnosis of pulmonary sarcoidosis, Plucne Bolesti, 2009, vol. 41, no. 1–2, pp. 18–21.
  12. Israel-Biet D., Valeyre D. Diagnosis of pulmonary sarcoidosis. Opin. Pulm. Med., 2013 22.
  13. James D.G. Sarcoidosis 2001, Med. J., 2001, vol. 77, no. 905, pp. 177–180.
  14. Laohaburanaki P., Clan A. Obstructive sarcoidosis, Rev. Allergy Immunol. 2013. vol. 25.2, pp. 115–130.
  15. Meyer K.C. Multidisciplinary discussions and interstitial lung disease diagnostic: how useful is a meeting of the minds? Lancet Respir Med., 2001, vol. 4 (7), pp. 529–531.
KEYWORDS:

sarcoidosis, ischemic heart disease, computed tomography, spirometry, diffusing capacity of the lung, echocardiography.

FOR CORRESPONDENCE:

Central TB Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Anver F. Abubikirov, Candidate of Medical Sciences, Senior Researcher, Department of Differential Diagnosis of Pulmonary TB and Extracorporal Treatments

Tel.: +7 (916) 126-86-33

Е-mail: abubik_1@mail.ru

Elena I. Leonova, Candidate of Medical Sciences, Researcher, Department of Differential Diagnosis of Pulmonary TB and Extracorporal Treatments

Tel.: +7 (906) 755-36-64

Е-mail: zei86@mail.ru

Larisa A. Mazaeva, Candidate of Medical Sciences, Researcher, Department of Differential Diagnosis of Pulmonary TB and Extracorporal Treatments

Tel.: +7 (903) 735-08-71

Е-mail: lara.mazaeva@yandex.ru

Alexander V. Medvedev, Candidate of Medical Sciences, Senior Researcher, Department of Differential Diagnosis of Pulmonary TB and Extracorporal Treatments

Tel.: +7 (909) 691-41-54

Е-mail: alexmedved_1@mail.ru

Evgeny I. Shmelev, Doctor of Medical Sciences, Head, Department of Differential Diagnosis of Pulmonary TB and Extracorporal Treatments

Tel.: +7 (499) 785-90-08

Е-mail: eishmelev@mail.ru

MODERN OPPORTUNITIES AND PRIORITIES OF TUBERCULOSIS CONTROL IN THE REPUBLIC OF MOLDOVA (dedicated to the 60th anniversary of Kirill Draganyuk Phthisiopulmonology Institute)

Article 8.Page 70.
ARTICLE TITLE:

Modern opportunities and priorities of tuberculosis control In the republic of moldova (dedicated to the 60th anniversary of kirill draganyuk phthisiopulmonology institute)

DOI:10.7868/S2587667819040083

AUTORS:

Javorsky K.M., Aleksandru S.M., Vilk V.V., Tudor E.M., Donika A.F., Bolotnikova V.A., Moskovchuc A.F., Brumaru A.G., Korlotyanu A.A.

Kirill Draganyuk Phthisiopulmonology Institute, Kishinev, Moldova

DESCRIPTION OF ARTICLE:

Submitted as of 17.09.2019

Based on the rich history of the Phthisiopulmonology Institute named after Kirill Draganyuk, we outlined the priority areas and the effectiveness of scientific research, treatment, methodology and administration of the institute in 2009–2018. We demonstrated, how we mobilized all resources and opportunities to set the goals of controlling/eliminating TB in the country in the period, when the WHO was changing its TB strategy. The data provided in the article reflected the dynamics of the main epidemiological indicators of TB burden. We also described the Phthisiopulmonology Institute acting as a principal research and treatment centre for TB control, which was responsible for the implementation of national TB programmes.

REFERENCES:
  1. Vasilyeva I.A., Belilovsky E.M., Borisov S.E., Sterlikov S.A. Incidence, mortality and prevalence as TB burden indicators in the WHO regions, different countries and the Russian Federation. Part 1. Incidence and prevalence of TB. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 6, pp. 9–21. (In Russ.)
  2. The global plan to stop TB 2011–2015: transforming the fight towards elimination of tuberculosis. WHO, 2010.
  3. The end TB strategy: global strategy and targets for tuberculosis prevention, care and control after 2015. Geneva, World Health Organization, 2014.
  4. Global Tuberculosis Report, 2017. WHO/HTM/TB/2016/13. Geneva: World Health Organization, 2017, p. 250.
KEYWORDS:

TB burden, epidemiological indicators, TB monitoring and control, screening, scientific research, medical care.

FOR CORRESPONDENCE:

Kirill Draganyuk Phthisiopulmonology Institute,

13, K. Vyrnav St., 2025, Kishinev, Moldova

Konstantin M. Javorsky, Professor, Deputy Director for Research and Innovation

Tel.: (+373) 22-57-22-04

E-mail: ciavorschi@gmail.com

Sophya M. Aleksandru, Director

Tel.: (+373) 22-57-22-01

E-mail: sofi.alexandru@gmail.com

Valentina V. Vilk, Deputy Director for Management and Strategy, National TB Programme Coordinator

Tel.: (+373) 22-57-22-03

E-mail: valentina_vilc@yahoo.co.uk

Elena M. Tudor, Scientific Secretary

Tel.: (+373) 22-57-23-50

E-mail: eltudor@yandex.ru

Anna F. Donika, Deputy Director for Treatment

Tel.: (+373) 22-57-22-02

E-mail: annadonica741@gmail.com 

Valentina A. Bolotnikova, Senior Researcher

Tel.: + (+373) 22-57-23-54

E-mail: ifp@ms.md

Anna F. Moskovchuk, Leading Researcher

Tel.: (+373) 069-192-829

E-mail: anamoscovciuc@yandex.ru

Albina G. Brumaru, Senior Researcher

Tel.: (+373) 079-470-322

E-mail: alibinabr@mail.ru

Andrey A. Korlotyanu, Head, NTP Coordination Department

Tel.: (+373) 22-57-22-30

E-mail: andreicorloteanu@mail.ru

IN VITRO ACTIVITY OF NANOSILVER COMBINATION WITH ISONIAZID AND RIFAMPICIN AGAINST MYCOBACTERIUM TUBERCULOSIS

Article 9.Page 76.
ARTICLE TITLE:

In vitro activity of nanosilver combination with isoniazid and rifampicin against mycobacterium tuberculosis

DOI:10.7868/S2587667819040095

AUTORS:

Nikonenko B.V.1, Majorov K.B.1, Revina A.A.2, Zakharov A.V.3, Ergeshov A.E.1

1 Central TB Research Institute, Moscow, Russia

2 A.N. Frumkin’ Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia

3 Regional clinic TB hospital, Yaroslavl, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 23.05.2019

The spread of strains of Mycobacterium tuberculosis (Mtb) resistant to anti-TB drugs requires the development of new drugs and approaches for treatment of tuberculosis infection. In addition to the development and creation of new anti-TB drugs, the use of silver nanoparticles (NS), which have a wide range of antibacterial activity, including Mtb is one of the promising directions in this area. In the present work it is shown that NS has in vitro high bactericidal activity against Mtb of museum H37Rv strain and isoniazid (INH)-resistant isolate CN‑40. When combining HC with INH and rifampicin (RIF) in different concentrations, the interaction is synergistic in activity against Mtb H37Rv.

The research was conducted under scientific research theme no. 0515-2019-0018 “Study of the mechanisms of the congenital and adaptive components of the immune response in tuberculosis and interstitial lung diseases”.

REFERENCES:
  1. Zakharov A.V., Khokhlov A.L., Ergeshov A.E. Silver nanoparticles in the solution to the problem of drug resistant tuberculosis. Archive of internal medicine, 2017, vol. 7 (3), pp. 188–199. (In Russ.)
  2. Zakharov A.V., Khokhlov A.L. Efficiency of application of silver nanoparticles on the model of clinical isolates of tuberculosis pathogen with different drug resistance. CTRI Bulletin, 2018, no. 1, pp. 64–75. (In Russ.)
  3. Nikonenko B.V., Kornienko A., Majorov K., Ivanov P., Kondratieva T., Korotetskaya M., Apt A.S., Salina E., Velezheva V. In Vitro Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium. Agents Chemother., 2016, vol. 60 (10), pp. 6422-4.
  4. Pandey R., Sharma A., Zahoor A., Sharma S., Khuller G.K., Prasad B. Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. Antimicrob. Chemother., 2003, vol. 52 (6), pp. 981-6.
  5. Reddy V.M., Einck L., Andries K., Nacy C.A. In vitro interactions between new antitubercular drug candidates SQ109 and TMC207. Agents Chemother., 2010, vol. 54 (7), pp. 2840-6.
  6. Zhao G., Stevens S.E. Jr. Multiple parameters for the comprehensive evaluation of the susceptibility of Escherichia coli to the silver ion. Biometals, 1998, vol. 11 (1), pp. 27–32.
KEYWORDS:

tuberculosis, Mycobacterium tuberculosis, drug resistance, silver nanoparticles, in vitro experiment.

FOR CORRESPONDENCE:

Central ТВ Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Boris V. Nikonenko, Doctor of Medical Sciences, Leading Researcher, Immunology Department

Tel.: +7 (499) 785-90-72

E-mail: boris.nikonenko52@gmail.com

Konstantin B. Majorov, Candidate of Biological Sciences, Senior Researcher, Immunology Department

Tel.: +7 (499) 785-90-72

E-mail: majorov@list.ru

Atadzhan E. Ergeshov, Doctor of Medical Sciences, Professor, Director

Tel. +7 (499) 785-90-19

E-mail: cniit@ctri.ru

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry

31 Build. 4, Leninsky Prospekt, 119071, Moscow, Russia

Aleksandra A. Revina, Doctor of Chemical Sciences, Professor

Tel.: +7 (495) 955-46-30

E-mail: Alex_revina@mail.ru

Yaroslavl Regional Clinical TB Hospital

43, Sobinova St., 150000, Yaroslavl, Russia

Andrey V. Zakharov, Candidate of Medical Sciences, Head, Pulmonary TB Department no. 2

Tel.: +7 (4852) 43-91-76

E-mail: yrzahan@mail.ru

DETECTION OF MYCOBACTERIA BY LUMINESCENCE MICROSCOPY

PART 2. MICROSCOPIC STUDY OF SMEARS

Article 10.Page 81.
ARTICLE TITLE:

Detection of mycobacteria by luminescence microscopy

part 2. Microscopic study of smears

DOI: 10.7868/S2587667819040101

AUTORS:

Sevastyanova E.V., Larionova E.E., Andrievskaya I.Yu., Smirnova T.G.

Central TB Research Institute, Moscow, Russia

DESCRIPTION OF ARTICLE:

Submitted as of 20.09.2019

We have described the microscopic detection of mycobacteria using luminescence staining of smears. We described the preparation procedures for a luminescence microscope and the techniques of microscopic examination. We proposed a method of quantitative recording of microscopic examination results based on the standard smear area. It was demonstrated that the number of examined visual fields varied depending on the magnification of a microscope. The numbers of visual fields, which provided the optimal smear area under different magnifications, were recommended.

REFERENCES:
  1. On improvement of TB control measures in the Russian Federation. Edict no. 109 by RF MoH as of 21.03.2003. Annex no. 11. A guideline to the unified methods of microbiology studies in TB detection, diagnosis and treatment. (In Russ.)
  2. Golyshevskaya V.I., Egorova O.V., Sevastyanova E.V., Shulgina M.V. Luminescence microscopy. A manual for training courses: Cultural methods of TB diagnosis, TB detection by microscopy. Moscow–Tver, Triada, 2008, 36 p. (In Russ.)
  3. Mycobacteriology Laboratory Manual. A publication of the Global Laboratory Initiative a Working Group of the Stop TB Partnership, 2014, 147 p.
KEYWORDS:

mycobacteria, luminescence microscopy

FOR CORRESPONDENCE:

Central TB Research Institute

2, Yauzskaya alley, 107564, Moscow, Russia

Elina V. Sevastyanova, Doctor of Biological Sciences, Leading Researcher, Microbiology Department

Tel.: +7 (499) 785-90-91

Е-mail: elinasev@yandex.ru

Elena E. Larionova, Candidate of Biological Sciences, Senior Researcher, Microbiology Department

Tel.: +7 (499) 785-90-91

E-mail: larionova_lena@mail.ru

Irina Yu. Andrievskaya, Researcher, Microbiology Department

Tel.: +7 (499) 785-90-91

Е-mail: andrievskaya.iri@mail.ru

Tatiana G. Smirnova, Candidate of Medical Sciences, Senior Researcher, Microbiology Department

Tel.: +7 (499) 785-90-91

Е-mail: s_tatka@mail.ru